SCSB Lunch Series: Social exposure to sickness enhances resilience to infection

Simons Center Conference room, 46-6011, 46-6011

Date: Friday, April 5, 2024 Time: 12:00pm – 1:00pm Location: Simons Center Conference room 46-6011 + Zoom Meeting (https://mit.zoom.us/j/98747295231)Speaker: Tomoe Ishikawa, Ph.D. Affiliation: Simons Postdoctoral Fellow, Choi Lab, Picower Institute, Department of Brain and Cognitive Sciences, MITTalk title: Social exposure to sickness enhances resilience to infectionAbstract: Animals change their social engagement based on the health status of their conspecifics to minimize infectious risk. However, it remains unclear whether animals also adjust their own immune status by detecting sick individuals. We have found that prior exposure to sick cagemates alleviates symptoms induced by viral and bacterial infections. This indicates that animals have a proactive immune response upon detecting sickness in their conspecifics. Furthermore, we demonstrated that exposure to sick animals activates an amygdala nucleus, and chemogenetic activation of this amygdala nucleus is sufficient to mitigate signs induced by viral and bacterial infections. These findings suggest that neuroimmune interactions activated by the detection of sick conspecifics modulate the immune system to better cope with subsequent pathogenic infections.