Have some fun(nel) on a tunnel or sun(nel) walk! Join us for a 30-minute volunteer-led walk either through MIT’s famous tunnel system or around Killian Court. As the weather gets warmer, walk leaders may choose to take the group outside. Is the weather warm and you missed the start? Find the group on Killian Court and join in!Location details: Meet in the lobby with the big mirror, right inside the Collier Memorial entrance to Stata. Location photo below.Sun(nel) Walk Leaders will identify themselves by holding a white flag at the meeting location.Prize Drawing: Attend a walk and scan a QR code from the walk leaders to be entered into a drawing for a getfit canvas boat tote bag at the end of the getfit challenge. The more walks you attend, the more entries you get. Winner will be drawn and notified at the end of April. Winner does not need to be a getfit participant.Disclaimer: These walks are led by volunteers. In the rare occasion when a volunteer isn’t able to make it, we will do our best to notify participants. In the event we are unable to notify participants and a walk leader does not show up, we encourage you to walk as much as you feel comfortable doing so. We recommend checking this calendar just before you head out!Getfit is a 12-week fitness challenge for the entire MIT community. These walks are open to the entire MIT community and you do not need to be a current getfit participant to join.

Ten minutes for your mind@2:50 every day at 2:50 pm in multiple time zones:Europa@2:50, EET, Athens, Helsinki (UTC+2) (7:50 am EST) https://us02web.zoom.us/j/88298032734Atlantica@2:50, EST, New York, Toronto (UTC-4) https://us02web.zoom.us/j/85349851047Pacifica@2:50, PST, Los Angeles, Vancouver (UTC=7) (5:50 pm EST) https://us02web.zoom.us/j/85743543699Almost everything works better again if you unplug it for a bit, including your mind. Stop by and unplug. Get the benefits of mindfulness without the fuss.@2:50 meets at the same time every single day for ten minutes of quiet together.No pre-requisite, no registration needed.Visit the website to view all @2:50 time zones each day.at250.org or at250.mit.edu

Title: Quantitative embeddings with applicationsSpeaker: Elia PortnoyZoom Link: https://mit.zoom.us/j/8509797390

Speaker: Shaowu Zhang (California Institute of Technology)Title: Spectral decomposition of nc-Hodge structures and F-bundlesAbstract: Non-commutative Hodge structures were introduced by Katzarkov, Kontsevich, and Pantev as a generalization of classical Hodge structures for non-commutative spaces. Their formal (or non-archimedean) analogs are known as F-bundles. Such structures naturally appear in mirror symmetry, enumerative geometry, and singularity theory.In this talk, I will first discuss the spectral decomposition of nc-Hodge structures of exponential type and relate it to the vanishing cycle decomposition after Fourier transforms via certain choices of Gabrielov paths. I will then discuss the spectral decomposition of maximal F-bundles. If time permits, I will also talk about the extension of framings for F-bundles and its applications. This talk is based on joint works with T. Yu, T. Hinaul, and C. Zhang.

Büchi Lectures with Abigail Doyle (UCLA)Talk Title: TBAhttps://doyle.chem.ucla.edu/abby/

Date: Thursday, April 3 Time: 4:00pm Location: 46-3002, Singleton Auditorium (Third floor of MIT Building 46)​​​​​​​ Zoom Link: https://us02web.zoom.us/j/89238458002Title: Human brain cell atlases powering basic and translational scienceAbstract: Single cell and spatial genomics methods are rapidly transforming our understanding of cellular diversity in the brain, and are so scalable that they are enabling the creation of comprehensive brain wide cell atlases in human and model organisms. These atlases are powerful resources akin to the human genome, and provide a unifying framework for understanding brain cellular architecture and its conservation and specialization across species. Furthermore, they can be used to identify regulatory sequences that can be used to create a new generation of cell type-selective perturbational tools to probe nervous system function across species. These tools are now proving to have immediate translational relevance, as they can be applied to identify vulnerable and affected cell populations in disease. Identifying the cellular locus of disease opens up new opportunities to selectively target those cell types as a therapeutic strategy. This talk will describe efforts in the NIH BRAIN Initiative Cell Atlas Network to create brain wide human and non-human primate cell atlases, how they can be used to gain new insights about cellular vulnerability in Alzheimer’s disease, and how cell selective genetic tools could lead to precision gene therapies for epilepsies and other diseases.Bio: Ed Lein is a Senior Investigator at the Allen Institute for Brain Science and an Affiliate Professor in the Departments of Neurological Surgery and Laboratory Medicine and Pathology (DLMP) at the University of Washington. He received a B.S. in biochemistry from Purdue University and a Ph.D. in neurobiology from UC Berkeley and performed postdoctoral work at the Salk Institute for Biological Studies. Ed joined the Allen Institute in 2004 and has provided scientific leadership for the creation of large-scale anatomical, cellular and gene expression atlases of the adult and developing mammalian brain as catalytic community resources, including the inaugural Allen Mouse Brain Atlas and a range of developmental and adult human and nonhuman primate brain atlases. Particular current research interests involve the use of single cell genomics as a core phenotype to understand brain cellular organization, mammalian conservation and human specificity, define cellular vulnerability in disease, and identify regulatory elements that allow cell type-specific targeting and manipulation. He leads the Human Cell Types Department, which aims to create comprehensive cell atlases of the human and non-human primate brain, understand what is disrupted in Alzheimer’s disease, and create tools for precision genetic targeting of brain cell types as transformative tools for basic neuroscience and gene therapy. He is also a member of the BRAIN Initiative Cell Atlas Network (BICAN), a member of the Organizing Committee of the Human Cell Atlas (HCA), and a CIFAR fellow. Ed's areas of expertise include developmental neurobiology, structural and cellular neuroanatomy, transcriptomics and epigenomics, comparative neurobiology, and Alzheimer’s disease. His research program work encompasses brain cell at lasing, comparative neurobiology, Alzheimer’s disease, and gene therapy.