Mechanistic insights into (bio)catalysts from unpaired electronsUnpaired electrons play an important role in numerous redox-driven catalytic processes. Controlling their location and exploiting the interactions with their environment can provide key mechanistic information into these catalytic reactions. In this talk Dr. Roessler will discuss how her research group is exploiting and developing EPR-based techniques in conjunction with biochemistry, electrochemistry and materials chemistry to gain mechanistic insights into metalloenzymes and electron-transfer based catalytic reactions more generally.Roessler will showcase how pulse EPR is helping to understand the proton-coupled electron transfer mechanism in respiratory complex I and then introduce film-electrochemical EPR spectroscopy (FE‑EPR) as a new tool to investigate surface-bound molecular catalysts, including enzymes. With operando FE-EPR we can monitor the evolution of radicals during catalysis in real time, providing a novel way to benchmark small-molecule electrocatalysts. Our current work is focussed on extending FE‑EPR to metalloenzymes and membrane proteins.

Poster Session at Cookies, Coffee & ScienceJoin us for a special edition of Cookies, Coffee & Science on Wednesday, April 2nd at 2:00 PM! This unique scientific event will feature a Poster Session, where you’ll have the opportunity to engage with presenters, and meet the newly admitted BCS graduate students to welcome them into our community!Listed below are the labs and poster presenters for the event:Corradin – Xochitl Luna: Connecting Noncoding Genetic Variants to Microglial Function in Multiple SclerosisMiller/Fiete – Adam Eisen: Propofol anesthesia destabilizes neural dynamics across cortexSur – Gregg Heller & Emma Odom: Integration of visually tuned inputs by pyramidal neurons in mouse visual cortexGabrieli – Gun Ahn: Predicting Suicidal Attempts Using Resting-State fMRI and Psychosocial Data: A Machine Learning Study from the ABCD CohortPoggio – Daniel Mitropolsky: Computation by Assemblies of Neurons, and Algorithms for LanguageTedLab – Thomas Clark: TBAFan – Adrienne Kashay & Navid Ghazi: Perturb and watch the brain in action: Toward the physical basis of learning and memoryDiCarlo – Yudi Li: What's behind? Modeling human visual inference relying on internal modelsFedorenko – Hope Kean: Deduction and Induction Dissociate in the Human BrainBoyden – Camille Mitchell: Towards in situ single-molecule protein sequencing with expansion microscopyHarnett – Mila Halgre: Cortical & thalamic population dynamics during a visually evoked 3-5 Hz rhythmHeiman – Francisco Garcia: Cell type-specific targeting of the brain vasculature delays progression of neurodegeneration in vivoMcDermott – Lakshmi Govindarajan: Confidence in Sound Localization Reflects Calibrated Uncertainty EstimationBrown - Karla "Ale" Montejo: Circuit And Metabolic Mechanisms Of Oscillatory Modulation Under Propofol And SevofluraneWe look forward to seeing you there!

In this small discussion group, we will examine Buddhist approaches to mindfulness, focusing attention, and developing self-compassion and compassion. Prof. Teng will provide tips on how these practices can help to navigate the stresses of academic life. Students will participate in guided meditation exercises. Sign-up is limited to eight students. Free books and meditation cushions will be provided.Emma J. Teng is the T.T. and Wei Fong Chao Professor of Asian Civilizations at MIT. She teaches classes in Chinese culture, Chinese migration history, Asian American history, East Asian culture, and women’s and gender studies. Professor Teng has published numerous books and articles and is a leading figure in her field. She has received various awards in recognition for her teaching and research.Free books and meditation cushions will be provided. Sign-up is limited to eight students.Location to be confirmed after registration.

The Spatial Distribution of Income in Cities: Cross-Country Evidence and Theory | David Lagakos

Ten minutes for your mind@2:50 every day at 2:50 pm in multiple time zones:Europa@2:50, EET, Athens, Helsinki (UTC+2) (7:50 am EST) https://us02web.zoom.us/j/88298032734Atlantica@2:50, EST, New York, Toronto (UTC-4) https://us02web.zoom.us/j/85349851047Pacifica@2:50, PST, Los Angeles, Vancouver (UTC=7) (5:50 pm EST) https://us02web.zoom.us/j/85743543699Almost everything works better again if you unplug it for a bit, including your mind. Stop by and unplug. Get the benefits of mindfulness without the fuss.@2:50 meets at the same time every single day for ten minutes of quiet together.No pre-requisite, no registration needed.Visit the website to view all @2:50 time zones each day.at250.org or at250.mit.edu

MIT Program in Polymers and Soft Matter (PPSM) Seminar