Yang Tan Collective Clinical Talk Series; Dr. Mustafa SahinTitle: Mechanism-based Biomarker and Treatment Trials in Tuberous Sclerosis.This presentation will review translational neuroscience research in a disease associated with high incidence of epilepsy and autism, tuberous sclerosis complex (TSC). Impactful research in TSC and related neurodevelopmental disorders will require reducing the boundaries between basic scientists and clinicians, between different departments and divisions as well as between academia and industry. Such research also allows for specialized centers of excellence to work in coordination with each other to address the challenges such rare genetic disorders raise.Bio: Dr. Mustafa Sahin is the Neurologist-in-Chief, a pediatric neurologist, and a developmental neurobiologist at Boston Children's Hospital as well as a Professor of Neurology at Harvard Medical School and the Rosamund Stone Zander Chair at Boston Children’s Hospital. He received his Sc.B. degree from Brown University and his M.D. and Ph.D. from Yale School of Medicine. He completed a pediatrics residency at Children's Hospital of Philadelphia and a child neurology residency at Boston Children's Hospital. At Boston Children’s, Dr. Sahin is the Director of the Translational Research Program, managing director of the Rosamund Stone Zander Translational Neuroscience Center, and the chair of Clinical and Translational Research Executive Committee. He is the co-PI of the Intellectual and Developmental Disabilities Research Center. He directs a national consortium to study biomarkers and comparative pathobiology in three genetic disorders (TSC, PHTS and Phelan McDermid Syndrome) all associated with autism and intellectual disability. He was elected to the National Academy of Medicine in 2023.

Dr. Mara Karlin from Johns Hopkins University will speak at the MIT Security Studies Program's Wednesday Seminar.In this seminar, Dr. Karlin will explore the legacies of the post-9/11 wars for the U.S. armed forces and discuss the implications of the changing character of military conflict.

A martial art known for its many health benefits, tai chi is a moving study in meditation.Designed for small spaces, this class covers fundamental skills including postures, hand, and footwork. A short Yang style tai chi form will be taught.Special clothing is not necessary, but athletic shoes and loose fitting pants are recommended.Registration is required on our wellness class website. If you do not already have an account on this website, you'll need to create one. This is fee-based class and open to the entire MIT community.

ORSEL presents concerts each month by MIT-affiliated artists, holding space in the Chapel for stillness and reflection — February 12, March 12, April 9, and May 14. Drop in anytime and enjoy tasty mORSELs after each concert!Valerie K. Chen, cello (February 12)Join EECS PhD student Valerie K. Chen for a midday contemplation of resilience, reconciliation, and compassion through the voice of the solo cello. Carson Marshall and Umer Piracha (March 12) Violinist and meditation guide Carson Marshall and Sufi vocalist Umer Piracha present a meditative sound experience blending classical violin improvisations with the rich vocal traditions of Sufi Qawwali. This collaboration explores deep listening, presence, and resonance through sustained melodic phrasing, the meditative drone of the tanpura, and immersive vocal textures. Leon Guallart Diaz (April 9)Leon Guallart is an artist from Barcelona, Spain, whose sound has been described as 'a warm hug in the middle of a snowstorm.' His current project, the Comfort: Home Tour, aims to bring warmth and comfort to iconic spaces around the world, designed by architects such as Frank Lloyd Wright, Eero Saarinen, or Mies van der Rohe. TBA (May 14) PREVIOUS ARTISTS:Carson Marshall and Natalie Lin Douglas (December 4)Violinist and Meditation guide Carson Marshall and MIT Associate Professor of Music Natalie Lin Douglas present a concert combining guided meditation with live classical music, providing tools for cultivating presence, deep listening, and emotional regulation. Musical selections will include works by Bach, Anna Clyne, and improvisations with violin and Shruti box.Past Concerts:Leo Eguchi: UNACCOMPANIED (November 6)MIT Affiliated Artist Leo Eguchi, cello, presents selections from his immigration themed solo performance project, UNACCOMPANIED, featuring newly commissioned works by immigrant and first generation American composers.Evan Ziporyn: Sonic Holograms (October 2)Evan Ziporyn, Kenan Sahin Distinguished Professor of Music at MIT & Faculty Director of MIT CAST, weaves live clarinet, bass clarinet, wind synth, effects boxes and loop pedals into a multidimensional, immersive and meditative auditory journey.Christine Southworth: Mushroom Modulations (September 4)Multi-media composer and MIT alum Christine Southworth will make music by “listening” to slight electrical variations in live colonies she has grown via electrodes placed on different parts of the fruiting growth and converted to sound.

Want to get exercise mid-day but don’t want to go outside? Join the tunnel walk for a 30-minute walk led by a volunteer through MIT’s famous tunnel system. This walk may include stairs/inclines. Wear comfortable shoes. Free.Location details: Meet in the lobby with the big mirror, right inside the Collier Memorial entrance to Stata. Location photo below.Tunnel Walk Leaders will have a white flag they will raise at the meeting spot for you to find them.Prize Drawing: Attend a walk and scan a QR code from the walk leaders to be entered into a drawing for a getfit tote bag at the end of the getfit challenge. The more walks you attend, the more entries you get. Winner will be drawn and notified at the end of April. Winner does not need to be a getfit participant.Disclaimer: Tunnel walks are led by volunteers. In the rare occasion when a volunteer isn’t able to make it, we will do our best to notify participants. In the event we are unable to notify participants and a walk leader does not show up, we encourage you to walk as much as you feel comfortable doing so. We recommend checking this calendar just before you head out! [As of Feb 28, this calendar is defaulting to the year 1899. Click "today" to be brought to the current month.]Getfit is a 12-week fitness challenge for the entire MIT community. These tunnel walks are open to the entire MIT community and you do not need to be a current getfit participant to join.

Complementarities in Labor Supply: How Joint Commuting Shapes Work Decisions | Florian Grosset

Ten minutes for your mind@2:50 every day at 2:50 pm in multiple time zones:Europa@2:50, EET, Athens, Helsinki (UTC+2) (7:50 am EST) https://us02web.zoom.us/j/88298032734Atlantica@2:50, EST, New York, Toronto (UTC-4) https://us02web.zoom.us/j/85349851047Pacifica@2:50, PST, Los Angeles, Vancouver (UTC=7) (5:50 pm EST) https://us02web.zoom.us/j/85743543699Almost everything works better again if you unplug it for a bit, including your mind. Stop by and unplug. Get the benefits of mindfulness without the fuss.@2:50 meets at the same time every single day for ten minutes of quiet together.No pre-requisite, no registration needed.Visit the website to view all @2:50 time zones each day.at250.org or at250.mit.edu

Time: 1:00 PMLocation: Cambridge, MA

For researchers interested in commercializing their new technology:● Learn what I-Corps is all about and what to expect in the program ● Explore the benefits of participating in our I-Corps short course ● What will the next steps be toward a potential $2MM in non-dilutive funding supportThere will be an opportunity for Q&A at the end of the session.

Speaker: Xin Jin (Boston College)Title: Multiplicative universal centralizer: Bruhat stratification, cluster structure and applicationsAbstract: The universal centralizer of a complex reductive group plays an important role in geometric representation theory. Aside from the standard group scheme structure, it possesses a natural Bruhat decomposition (and consequently a ''parabolic induction" structure) that makes the geometry quite explicit, and has many applications.The multiplicative version of the universal centralizer possesses a similar feature but has much richer (and more complicated) algebraic geometric structures. I will talk about recent results on several geometric features of the multiplicative universal centralizer. These include (a complete description of) a natural Bruhat stratification and the cluster structure on it. I will also talk about several applications. This is based on joint work with Ben Webster.

Talk Title: A cellular basis for mapping behavioural structureAbstract: To flexibly adapt to new situations, our brains must understand the regularities in the world, as well as those in our own patterns of behaviour. A wealth of findings is beginning to reveal the algorithms that we use to map the outside world. However, the biological algorithms that map the complex structured behaviours that we compose to reach our goals remain unknown. Here we reveal a neuronal implementation of an algorithm for mapping abstract behavioural structure and transferring it to new scenarios. We trained mice on many tasks that shared a common structure (organizing a sequence of goals) but differed in the specific goal locations. The mice discovered the underlying task structure, enabling zero-shot inferences on the first trial of new tasks. The activity of most neurons in the medial frontal cortex tiled progress to goal, akin to how place cells map physical space. These ‘goal-progress cells’ generalized, stretching and compressing their tiling to accommodate different goal distances. By contrast, progress along the overall sequence of goals was not encoded explicitly. Instead, a subset of goal-progress cells was further tuned such that individual neurons fired with a fixed task lag from a particular behavioural step. Together, these cells acted as task-structured memory buffers, implementing an algorithm that instantaneously encoded the entire sequence of future behavioural steps, and whose dynamics automatically computed the appropriate action at each step. These dynamics mirrored the abstract task structure both on-task and during offline sleep. Our findings suggest that schemata of complex behavioural structures can be generated by sculpting progress-to-goal tuning into task-structured buffers of individual behavioural steps.Bio: Tim Behrens is a neuroscientist at Oxford and UCLWebinar Link: https://us02web.zoom.us/j/89002014229?pwd=bzZuZGh6cVhOSjJ6TlNZVHgrRnNaQT09Followed by a reception with food and drink in 3rd floor atrium

Want to get exercise toward the end of the day but don’t want to go outside? Join the tunnel walk for a 30-minute walk led by a volunteer through MIT’s famous tunnel system. This walk may include stairs/inclines. Wear comfortable shoes. Free.Location details: Meet in the lobby with the big mirror, right inside the Collier Memorial entrance to Stata. Location photo below.Tunnel Walk Leaders will have a white flag they will raise at the meeting spot for you to find them.Prize Drawing: Attend a walk and scan a QR code from the walk leaders to be entered into a drawing for a getfit tote bag at the end of the getfit challenge. The more walks you attend, the more entries you get. Winner will be drawn and notified at the end of April. Winner does not need to be a getfit participant.Disclaimer: Tunnel walks are led by volunteers. In the rare occasion when a volunteer isn’t able to make it, we will do our best to notify participants. In the event we are unable to notify participants and a walk leader does not show up, we encourage you to walk as much as you feel comfortable doing so. We recommend checking this calendar just before you head out! [As of Feb 12, this calendar is defaulting to the year 1899. Click "today" to be brought to the current month.]Getfit is a 12-week fitness challenge for the entire MIT community. These tunnel walks are open to the entire MIT community and you do not need to be a current getfit participant to join.

We have two Sign Language Study Breaks coming up, with free Cafe 472 pizza and activities for all skill levels! When #1: Wed, March 12th, 4:30-6:00pmWhen #2: Wed, March 19th, 4:30-6:00pmWhere: MIT building 4, room 4-145What: Sign language practice + Cafe 472 pizzaRSVP (encouraged): https://asl.mit.edu/asl-study-break-rsvp-march-2025/ Come to socialize, learn the ASL fingerspelling alphabet, practice some basic signs, play sign language games, and for more experienced signers, we can practice conversational skills. All MIT community members are welcome! An ASL interpreter will be provided. Please RSVP to notify us of any other accommodations needed.

Spring recruiting is here, and is your LinkedIn “recruiter ready”? Does your headline need some attention? Not sure what to put “about me”? Through this 60-minute workshop you will learn ways to make your LinkedIn profile an “all-star”.This CAPD event is open to MIT undergraduates, graduate students, postdocs, and alumni.

For Researchers Interested in Commercializing their New TechnologyExplore taking your new technology to the marketplace Get entrepreneurial training, support to identify customers Learn how to apply for $50,000 from the NSFIncrease your chances of receiving an SBIR/STTR awardClick here for more details

Time: 4:00 PMLocation: Boston, MA

Time: 4:00 PM ET (3:00 PM CT)Location: San Antonio, TX

Every Wednesday night you are invited to come to The Table for peaceful Christian worship in the Chapel at 5:15 pm and dinner in the Main Dining Room of W11 at 6:30 pm.We worship with beautiful songs, open conversation about the Scriptures, prayers and a simple sharing of communion around the altar. Then we enjoy dinner together and good company together. Whether you come every week or just drop by once in a while, there is a caring community for you at the Table.You are truly welcome to come as you are: undergrad, grad, or post-doc; sure of your faith or wondering what it is all about; gay, straight, bi, trans*, questioning. Please join us for no-pressure worship and fellowship.Hosted by the Lutheran Epsicopal Ministry @ MIT. For more information, or to verify gathering times during holiday and vacation periods, please contact chaplains Andrew Heisen (heisen@mit.edu) and Kevin Vetiac (kvet246@mit.edu).