On view in the Hayden Library Loft (Floor 1M) May 12 - September 30, 2025Throughout her life, Katharine Dexter McCormick widened the horizons of what was possible for women. A suffragist, philanthropist, and scientist, she broke boundaries from an early age, becoming one of the first women to graduate from MIT. She later went on to fund McCormick Hall, the first on-campus dormitory for women at MIT. Learn more about the exhibit

February 26, 2025 - September 4, 2025Hidden within MIT’s Distinctive Collections, many architectural elements from the earliest days of the Institute’s architecture program still survive as part of the Rotch Art Collection. Among the artworks that conservators salvaged was a set of striking windows of gypsum and stained-glass, dating to the late 18th- to 19th c. Ottoman Empire. This exhibition illuminates the life of these historic windows, tracing their refracted histories from Egypt to MIT, their ongoing conservation, and the cutting-edge research they still prompt.The Maihaugen Gallery (14N-130) is open Monday through Thursday, 10am - 4pm, excluding Institute holidays.

Ten minutes for your mind@2:50 every day at 2:50 pm in multiple time zones:Europa@2:50, EET, Athens, Helsinki (UTC+2) (7:50 am EST) https://us02web.zoom.us/j/88298032734Atlantica@2:50, EST, New York, Toronto (UTC-4) https://us02web.zoom.us/j/85349851047Pacifica@2:50, PST, Los Angeles, Vancouver (UTC=7) (5:50 pm EST) https://us02web.zoom.us/j/85743543699Almost everything works better again if you unplug it for a bit, including your mind. Stop by and unplug. Get the benefits of mindfulness without the fuss.@2:50 meets at the same time every single day for ten minutes of quiet together.No pre-requisite, no registration needed.Visit the website to view all @2:50 time zones each day.at250.org or at250.mit.edu

For Researchers Interested in Commercializing their New TechnologyLearn what I-Corps is all about and what to expect in the programExplore the benefits of participating in our I-Corps short courseWhat will the next steps be toward a potential $2MM in non-dilutive funding supportThere will be an opportunity for Q&A at the end of the session

Aging Brain Seminar with Ramon Sun, PhD, University of FloridaDate: Tuesday, August 5Time: 4:00pmLocation: Picower Seminar Room (46-3310)Talk Title: Hyper-Glycosylation as a Central Metabolic Driver of Alzheimer’s DiseaseAbstract: Alzheimer's disease (AD) is a neurodegenerative disorder characterized by devastating degenerative decline. Metabolic disruptions are widely observed, yet their involvement in the molecular etiology of AD remains underexplored. Utilizing spatial metabolomics, lipidomics, and glycomics in both mouse models and human post-mortem samples, we identified a hyper-glycosylation phenotype as a hallmark of AD. To investigate the underlying mechanisms and whether the observed effect was a driver of the observed decline, we developed an advanced spatial isotopic tracing pulse-chase method to study the dynamics of N-linked glycans. Our analysis revealed enhanced glycan biosynthesis in AD mouse models. Based on these findings, we performed genetic and dietary interventions to modulate glycan biosynthesis. Genetic knockdown of glycan biosynthetic enzymes ameliorated the hyper-glycosylation and improved cognitive and behavioral outcomes in AD mice. In contrast, oral glucosamine supplementation drove hyper-glycosylation and exacerbated cognitive and behavioral deficits. To assess the clinical relevance of these findings, we conducted a retrospective analysis of a large population of patients with mild cognitive impairment (MCI), AD, and Alzheimer's Disease Related Dementias (ADRD) stratified by glucosamine use, leveraging electronic health records. Consistently, glucosamine supplementation was associated with increased mortality in AD and ADRD patient cohorts, and significantly elevated progression from MCI to AD compared to age-matched controls. Collectively, our findings establish hyper-glycosylation as a pathological driver of AD and highlight glycan metabolism as an actional target in the fight against AD.Bio: Dr. Ramon Sun is a leading researcher in spatial biology, pioneering the development of next-generation spatial metabolomics to decode the biochemical basis of physiology and disease. His work integrates advanced mass spectrometry, imaging technologies, and artificial intelligence to map metabolic processes in space and time. Dr. Sun’s lab has developed a suite of AI-powered analytical platforms that transform spatial metabolomics data into mechanistic hypotheses, which are then systematically tested using human biospecimens and transgenic mouse models. These efforts have led to major discoveries in the molecular underpinnings of aging, cancer, and neurological disorders.----------About The Aging Brain InitiativeThe Aging Brain Initiative is a interdisciplinary research effort that pulls together faculty expertise, knowledge, and technical resources from across MIT to solve the mysteries of the aging brain. It spans neuroscience, fundamental biology and genetics, investigative medicine, engineering and computer science, economics, chemistry, urban planning, and artificial intelligence to enable a comprehensive systems approach. What's the ultimate mission? To deliver the basic research that makes possible new tools to address the challenges of brain aging and create a better future for millions. Read more here: https://picower.mit.edu/research/aging-brain-initiative

Get outside and play! Bananagrams, Connect Four, Hopscotch, Scrabble, Corn Hole, and more.Choose from a fun and varied selection of board games and lawn games, all free to borrow during your visit. Plenty of options available for adults, kids, small groups and pairs.Picnics, dogs, and groups are welcome! Just make sure to follow our guidelines.Free and open to all! Please note that this event is weather dependent.Special Play+ events in this series:7/22 - Free ice cream sandwiches while supplies last! 🍦7/29 - Rescheduled8/5 - The theme this week is Board Games!8/12 - The theme this week is Lawn Games!8/19 and 9/2 - Free lemonade while supplies last! 🍋10/14 Pet Rock Painting